Results Page

Analysis Details

Mahalanobis Plot

Threshold (at --% confidence level) --

Mahalanobis Distance (MD)

Prediction MD --

Reference (--) MD --

Prediction ↔ Reference MD --

FoldaVirus Score --

The Foldavirus Score is estimated as

Foldavirus Score = max( Threshold − Prediction MD, Threshold − MD between Prediction and Reference )

Energy Analysis

Interface	Symmetry	Association Energy (Kcal/mol)	Buried Surface Area (Å)	Solvation Energy (Kcal/mol)	Relative Strength (% BSA)

Important Considerations

The association and solvation energies shown in the table above were calculated based on buried surface areas and atomic solvation parameters. We strongly believe that the relative energies (i.e., strengths of the interfaces) are reflected in these numbers. Use them with caution when comparing with experimental values.

References

Reddy, V. S., Giesing, H. A., Morton, R. T., Kumar, A., Post, C. B., Brooks, C. L., 3rd, & Johnson, J. E. (1998). "Energetics of quasiequivalence: computational analysis of protein-protein interactions in icosahedral viruses."
Biophysical Journal, 74(1), 546–558. PMID: 9449355
Horton, N., & Lewis, M. (1992). "Calculation of the free energy of association for protein complexes."
Protein Science, 1(1), 169–181. PMID: 1339024
Eisenberg, D., & McLachlan, A. D. (1986). "Solvation energy in protein folding and binding."
Nature, 319(6050), 199–203. PMID: 3945310

Residue Types:

A Acidic

B Basic

H Hydrophobic

NA Nucleic Acid

P Polar, uncharged

Individual Contacts

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Contacts by Interface

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References

FoldaVirus, a knowledge-based icosahedral capsid builder using AlphaFold Primary Citation

Oscar Rojas Labra, David S. Montoya-Munoz, Nelly Santoyo-Rivera, Jeffrey McDonald, Daniel Montiel-Garcia, David A. Case, Vijay S. Reddy bioRxiv (2026). 10.64898/2026.03.27.714795

Highly accurate protein structure prediction with AlphaFold Jumper, J., Evans, R., Pritzel, A., et al. Nature 596, 583–589 (2021). 10.1038/s41586-021-03819-2

Protein complex prediction with AlphaFold-Multimer Evans, R., O’Neill, M., Pritzel, A., et al. bioRxiv (2021). 10.1101/2021.10.04.463034

Disclaimer

Research Use Only — Not for Clinical Application AlphaFold2 predictions are intended for theoretical modeling purposes only. The AlphaFold data has not been validated for, and is not approved for, any clinical use, and should not be used as a substitute for professional medical advice, diagnosis, or treatment.

No Warranty — Data Provided "As Is" All predictions and associated data are provided "as is", without any warranty of any kind, whether expressed or implied. No warranty is given that the use of the information shall not infringe the rights of any third party. Scientific caution is strongly advised.

UniProtKB:
Taxonomy ID:

Genus:
T-Number:
Diameter:	-- min -- avg -- max
Ref. Structure (TM-score / RMSD):

FoldaVirus

Prediction Confidence (pLDDT)

Model Attributes

Structure View

General Information

VIPER Analysis & Annotations

Analysis Details

Residue Annotations Analysis

Mahalanobis Plot

Surface Profile Analysis

Energy Analysis

Important Considerations

References

Individual Contacts

Contacts by Interface

References

Disclaimer